Poly-nucleotides

Transform Your Skin with Polynucleotides

Understanding Polynucleotides

In the realm of regenerative aesthetics, navigating through the multitude of treatment options can be overwhelming. Each treatment offers unique benefits, often overlapping with others, making it challenging for patients to decide which one suits their skin goals best. Polynucleotides, commonly referred to as polynucleotide therapy or PDRN therapy, stand out as an innovative solution in this landscape.

Derived from salmon or trout sperm, polynucleotides have been utilized in medicine for over 40 years for tissue regeneration. These ultra-purified nucleotides, the building blocks of DNA and RNA, closely mimic human DNA. When combined into an injectable gel and administered to the skin, they act as messenger molecules, stimulating fibroblasts and enhancing cellular activity. This results in increased collagen, elastin, and hyaluronic acid production, along with other vital components of the extracellular matrix.

The Benefits of Polynucleotide Therapy

Polynucleotide therapy offers a wide array of benefits:

Boosting collagen and elastin production, enhancing skin elasticity and firmness.
Diminishing wrinkles, fine lines, and sagging skin.
Improving skin hydration, texture, and overall appearance.
Reducing inflammation and redness.
Addressing hyperpigmentation, sun damage, scarring, stretch marks, and acne.

Treatment Areas and Targeted Concerns

Polynucleotides can be injected into various areas of the body, including:

Undereye area
Forehead
Mouth area
Cheeks
Whole face
Neck
Décolletage
Abdomen
Knees
Inner arms

This versatility makes polynucleotide therapy suitable for addressing a wide range of skin quality, laxity, texture, and tone concerns.

Recommended Treatment Plan

For optimal results, an initial course of 2-3 treatments, spaced 2-4 weeks apart, is recommended. Visible improvements typically begin within about 6 weeks after treatment, with continued enhancement over the following 3 months. Maintenance treatments are advised every 6-9 months to sustain results.

Potential Risks and Complications

Polynucleotide therapy is generally safe, with minimal risk of complications. Temporary bruising and swelling may occur post-treatment but typically resolves within a few days. Although, as with any treatment, it is possible to have an allergic reaction, it is extremely rare and even having a fish allergy doesn’t necessarily preclude you from having this treatment.

Ready to Explore Polynucleotide Therapy?

If you're interested in learning more about polynucleotide therapy and how it can benefit your skin, we invite you to schedule a free consultation at Peppermint Clinic. Our experienced practitioners will provide personalized guidance and tailor a treatment plan to address your unique skin goals. Contact us today to take the first step towards rejuvenated, radiant skin.

Procedure Time

30 minutes approx

Results & Benefits

Regenerate & Restore

Maintenance

Every 6-9 months

Results Within

6 weeks to 3 months

Downtime

Minimal

Potential Effects

Minor swelling/bruising

Treatment Prices

Initial Course:

2x Treatments 2-4 weeks apart

£405

3x Treatments 2-4 weeks apart

£605

Maintenance Treatment:

1x Treatment every 6-9 months

£225

Please note that the price for one treatment is for 1 x 2ml syringe of polynucleotides.

This would be suitable for one area, such as both eyes, the mouth/chin area, and forehead. For both cheeks or the neck 2 x 2ml syringes would be necessary. Larger areas will need multiple syringes of product.

What areas can be treated?

It is most often used on forehead lines, crow’s feet, and frown lines. It can also be used for other areas such as the mouth and neck whilst also being an approved treatment for migraine relief and excessive underarm sweating – Check out our menu to read more about our advanced injectable aesthetics treatments.
How long until I see visible results?

You will not see a result straight away. It takes 2-3 days* to begin working, and approximately 2-3 weeks* to see the full effect. If after 3 weeks you are not 100% satisfied, get in touch with us and we can book you in for a top-up treatment free of charge. *Alluzience® begins working within 24 hours so visible results may be seen sooner than with standard botulinum toxin-a products.
How long do the results last for?

Botox® and Azzalure® generally last 3-4 months. There will certainly be patients in which it lasts longer, in the 4–6-month range, or shorter, in the 2-month range. It is also common for first time users to notice that it may not last as long initially but may last longer after the second treatment. Alluzience® is an advanced botulinum toxin-a new wrinkle-relaxing injection launched by Galderma, the world’s largest independent dermatology company). It starts to work sooner than other standard botulinum toxin brands and can last up to 6 months. Individual lifestyle choices may affect the longevity of the treatment e.g. people who exercise a lot or are very expressive may find the effects fade faster.
What products do we use at Peppermint Clinic?

We use Botox®, Azzalure® and a fairly new product called Alluzience®. Alluzience® has the potential to last up to 6 months so you can reduce the number of treatments you undergo per year, but it is not suitable for all areas. If you have questions, please contact us to discuss the individual products in more detail or book a free consultation to come in and have all your questions answered and discuss your suitability for the treatment, your goals, and expectations in more detail.
Does it hurt?

Pain is very subjective and personal - how we feel pain varies a lot from person to person and from time to time, e.g. studies have shown that women rate pain significantly higher in menstrual and premenstrual phases than during the rest of their cycle. A small pinch or sting that you would expect from inserting a small needle into any part of the body and you may feel a brief stinging sensation. The site of injection also influences the sensation of pain e.g. injections around the lips might feel more sensitive than those on the forehead.
Pre-treatment do’s & don’ts

Schedule your appointment at least 4 weeks prior to any special event or holiday to allow time for complete healing and optimal results. Reschedule your appointment if you develop a rash, cold sore or blemish in the treatment area. You should avoid taking blood thinning medications and anti-inflammatory medicines like ibuprofen for the 2 weeks leading up to your treatment. Also avoid aspirin, vitamin E, ginkgo biloba, ginseng, St. John's Wort, and Omega 3/Fish Oil supplements. You may wish to consider taking arnica tablets, available from most pharmacies, for one week prior and one week post treatment can help reduce the risk of swelling and bruising. Avoid alcoholic beverages at least 24 hours prior to treatment. Alcohol may thin the blood and increase the risk of bruising. Discontinue Retin-A two (2) days before and two (2) days after treatment.
Post-treatment do’s & don’ts

Avoid any strenuous activity or exercise for 24 hours after treatment. Avoid aggravating the injection site by rubbing or massaging the area. After 6 hours, you may gently wash the injection site but not before then. Avoid lying down for the first 4 hours post treatment. It is best to avoid alcohol for 24 hours post treatment. If possible, do not restart any blood thinning medication for several days after your treatment. If you are taking prescription blood thinning medication, please contact us to discuss your treatment options or book a free consultation to discuss this aspect of your treatment further. Avoid heat, tanning, self-tan, and tanning beds for 72 hours post treatment. Avoid any facials, laser treatments, or microdermabrasion for a minimum of 10 days following your procedure. If you are unsure about how long to wait before having a certain procedure, contact us or ask your practitioner during your appointment. Using a good sunscreen will protect the longevity of your treatment. Wearing sunglasses to reduce squinting will protect the longevity of your treatment.

The Science Behind It

Polynucleotides, derived from salmon or trout sperm, consist of complex nucleotide chains that mimic the structure of human DNA and RNA. When introduced into the skin via injection, these polynucleotides interact with cellular receptors, triggering a cascade of intracellular signalling pathways. This leads to the activation of fibroblasts, specialized cells responsible for producing collagen, elastin, and other extracellular matrix components.

The presence of polynucleotides enhances the transcription and translation processes within fibroblasts, resulting in increased synthesis of structural proteins such as collagen and elastin.

Additionally, polynucleotides stimulate the production of hyaluronic acid, a key molecule involved in maintaining skin hydration and elasticity.

As a result of these cellular responses, polynucleotide treatments promote skin rejuvenation and regeneration. Collagen and elastin deposition contribute to improved skin firmness, elasticity, and texture, while increased hyaluronic acid levels enhance skin hydration and volume. Furthermore, polynucleotides exhibit antioxidant and anti-inflammatory properties, further supporting skin health and resilience.

Breaking it Down

Polynucleotides are tiny molecules derived from fish sperm that help our skin cells work better. When we inject these molecules into the skin, they tell our cells to make more collagen, which makes the skin firmer and smoother. They also help to keep the skin hydrated and protect it from damage. So, polynucleotides can make our skin look younger and healthier.

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Poly-nucleotides