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Writer's picturePeppermint Clinic

Polynucleotides - Everything You Need to Know

Updated: Nov 7

Whilst it is without doubt a very exciting time within the aesthetics industry, yet for many patients, it can also be a labyrinth of choices. With a plethora of innovative products falling under the umbrella of "regenerative aesthetics," it's understandable that choosing the right treatment to achieve one's skin goals can feel perplexing. 


The confusion arises from the overlapping benefits of these injectable rejuvenation treatments. While some benefits may intersect, each treatment typically boasts a primary benefit or targets specific areas for improvement.

 

With that in mind, it can yield optimal results by blending a combination of these regenerative treatments into a personalised treatment plan as it addresses skin concerns holistically rather than solely relying on one type of treatment to reach your skin goals.

 

Of course, cost considerations come into play as well. While we offer competitive pricing and financing options, it's essential to maximise the effectiveness of your investment in skincare.

 

So, when faced with the decision between a skin booster, Profhilo®, or polynucleotides, how do you choose?

 

To demystify the options, we've written detailed articles on each treatment. You can explore our insights on Restylane® Skinboosters™ and Profhilo® to gain clarity on which treatment aligns best with your needs.

 

Now, let's delve into polynucleotides – the latest innovation in regenerative aesthetics.

DNA strand

Derived from salmon or trout sperm, polynucleotides boast over 40 years of medical use in tissue regeneration, establishing a robust evidence base and safety profile. These complex chains of nucleotides, akin to human DNA, are meticulously filtered, ultra-purified, and sterilised before being incorporated into an injectable gel.


Upon administration, polynucleotides act as messenger molecules, stimulating an increase of fibroblasts in the skin and boosting their activity which ramps up collagen, elastin, and hyaluronic acid production, along with other components of the extracellular matrix.

 

The result? As this cellular activity increases, collagen production goes up (47% in 23 days), skin elasticity increases (38% in 20 weeks) and hydration improves (115% in 20 weeks). Your skin will have a thicker, healthier epidermis (52% in 23 days), and wrinkles will diminish.

 

Moreover, polynucleotides exhibit antioxidant and anti-inflammatory properties – they have been used medically to treat severe eczema and psoriasis for many years. They also function as wound healing agents which can improve scars, reduce stretch marks, and improve skin texture concerns.

 

What are the main benefits of this treatment?

 

Polynucleotides are the gold standard for:

 

Boosting collagen and elastin to improve skin elasticity and firmness.

Reduce appearance of wrinkles, fine lines and sagging skin.

Improve skin hydration and texture.

Reduce inflammation and redness.

Treating hyperpigmentation, sun damage, scarring, stretch marks and acne.

 

Where can they be injected? And what skin concern would most benefit from this treatment?

 

From the under-eye area to the décolletage and beyond, polynucleotides offer a comprehensive solution for skin quality, laxity, texture, and tone issues across the entire body.

 

Particularly noteworthy is their efficacy in rejuvenating challenging areas like the under-eye region, often neglected by traditional treatments. Botox® primarily targets dynamic wrinkles but doesn’t really help with static lines and anti-ageing under the eye. Profhilo® whilst an excellent treatment is not suitable for the under-eye area.

 

Commonly this area has been treated with tear trough dermal filler which can work well for people whose main concern is hollows under the eye but if your concerns are dark circles or fine lines/crepey skin and you are prone to under-eye puffiness then polynucleotides offer a more natural, long-lasting solution to both rejuvenate and brighten the under-eye area. It can also be injected into the crow’s feet areas and the top or the eye along the brow bone so it’s fantastic for rejuvenating the entire eye area giving you a fresher more youthful appearance.

 

They're also ideal for addressing peri-oral lines (smoker’s lines) around the mouth without augmenting volume, as would be the case with dermal filler.

 

For those grappling with rosacea or eczema, polynucleotides' anti-inflammatory properties offer relief and rejuvenation.

The décolletage, often prone to visible sun damage, can undergo remarkable rejuvenation with polynucleotides. Their antioxidant properties not only revitalise this area but also shield the skin from future damage.

 

Furthermore, let's not overlook other areas of the body. Sagging skin on the abdomen, above the knees, and the inner arms can experience significant improvement with this treatment.

 

How many treatments are recommended, and what about visible results and longevity?

woman getting polynucleotides injection

An initial course of 2-3 treatments spaced 2-4 weeks apart is typically recommended.

Obviously, it takes some time for the cellular level changes to take place once you’ve had this treatment, so it is not a quick fix treatment. While noticeable improvements may start to manifest within 6 weeks, the full benefits become evident over 3 months, with the full impact of the course of treatments being seen within 3 months of your last treatment.

 

To maintain the positive changes to your skin a maintenance treatment is advised every 6-9 months are advised.

 

Are there any risks or possible complications?

 

Thanks to stringent extraction and purification processes, adverse reactions are rare. Temporary bruising or swelling may occur, but serious complications are exceedingly uncommon.

 

Ready to embark on your journey to rejuvenated skin with polynucleotides?

 

Book a free consultation with us at Peppermint Clinic to explore this transformative treatment further. Whether you reach out via our contact page or book online, we're here to guide you towards radiant, revitalised skin.

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